Lions vs. Patriots Prediction, Odds, Pick For NFL Week 10

The Detroit Lions will face the New England Patriots on Sunday in a Week 10 NFL showdown on FOX in Munich, Germany. 

Let’s take a look at the odds for Lions vs. Patriots at FanDuel Sportsbook as of Nov. 15.

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Moneyline

• Lions: -148
• Patriots: +124

Unfold

• Lions -2.5: -108
• Patriots +2.5: -112

Over/Beneath

• Over 51.5: -102
• Under 51.5: -118

From FOX Sports activities Analysis: 

• Detroit ranks fifth in the NFL at 27.8 points per game. After three straight games scoring 20 or fewer, the Lions face a Patriots defense that just gave up 45 to Green Bay and has allowed 30-plus three times this season.
• New England is 0-3 when it fails to force a takeaway. Detroit has committed just five giveaways all season, tied for the second fewest in the NFL, which could make it tough for the Patriots to cut drives short.
• Drake Maye has accounted for at least three touchdowns in six straight games, the longest active streak in the NFL. He leads the league with eight touchdown passes of 20-plus air yards, and Detroit has allowed five on those throws, tied for the second most.
• Maye has thrown for 832 yards against the blitz, second most in the NFL. Detroit ranks second with 12 sacks when blitzing, so Maye has a chance to turn one of the Lions’ biggest strengths into explosive plays.
• Jahmyr Gibbs leads the NFL with 1,132 scrimmage yards and is tied for the league lead with 11 touchdowns.

Find out how to Watch Lions vs. Patriots

• Date: Sunday, Nov. 15, 2026
• Time: 9:30 a.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: FC Bayern Munich Stadium, Munich, Germany